MD Life L Methylfolate 1mg - Professional-Grade Active Methylfolate Supplement - Maximum Potency MTHFR Supplements - L methylfolate 1mg 30 Capsules - Essential Amino Acids

My doctor recommended me to take Methyl folate and vitamin B12 (Methylcobalamin) which usually are taken together. To make matters confusing methyl folate is also known as L-Methylfolate, L-5-Methylfolate, MTHF, L-5-MTHF, but they are the same thing as far as a supplement is concerned.This bottle comes with a normal twist cap (not a childproof cap.) These are two-piece hard-shelled capsules but easy to swallow. I did not feel any after-taste with these pills. The shells for these capsules seem to be gelatin-free and made from vegetable derivatives since the bottle mentions Vegetarian Capsules.Methylfolate would usually be recommended if the Doctor suspects methylation issues with the body or the MTHFR gene test shows a gene mutation. Methylfolate plays an important part in methylation and issues with production of methyl folate can result in several problems.I had been using methylfolate from other company which were more expensive ProHealth Methylfolate with Quatrefolic (15 mg - 60 capsules). But I have been using these capsules since these are ore closer to the amount prescribed by my doctor.WHAT IS METHYLATIONMethyl molecule (depicted as CH3) plays an important part in various chemical processes in the body. Various biochemical processes involve transferring methyl molecule and transfer of this molecule is called methylation. During methylation, the methyl molecule is given away by S-adenosylmethionine (or SAMe.) Production of SAMe in the body depends upon methyl folate. So if the body doesn't have enough methylfolate, then body might not be able to produce enough SAMe and thereby impacting methylation.WHAT ARE ISSUES RELATED WITH METHYLATIONIssues with methylation can manifest in several different ways. Methylation issues may hamper brain's ability to convert amino acids into neurotransmitters such as serotonin, dopamine, norepinephrine, and acetylcholine resulting in depression, mood swings, delusions, phobias, etc. Methylation issues with other bodily functions may result in fatigue, inflammation, pain and several other problems. Hypomethylation (decrease in methylation) is linked to cancer as well (search for the paper titled "DNA hypomethylation in cancer cells".) However, lots of new information is coming up on this topic and the already known information is becoming outdated because of the new folate studies. So it is advisable to stick to Doctor's recommendation on if and how much methylfolate to take.WHAT CAN CAUSE METHYLATION ISSUESOne of the major reasons for methylation issues is the body's inability to convert folate to methylfolate. The human body gets folate (from the food source such as green vegetables) or synthesized folate i.e. folic acid a.k.a. Vitamin B9 as a supplement. Folate or Folic acid gets converted into methylfolate by the body with the assistance of several genes and enzymes such as MTHR gene, BHMT gene, CBS gene, etc. However, a mutation in the MTHR gene may result in the body being unable to make sufficient quantity of methylfolate from folic-acid/folate. It is estimated that around 30-50% of people in the US have this mutation. This gene mutation may affect different people in different ways and to different severities.HOW DO I KNOW IF I HAVE MTHR GENE MUTATIONMTHR gene mutation can be detected with MTHR gene tests: MTHFR C677T and MTHFR A1298C (for the two main MTHFR gene mutations). You can ask your doctor about this test. Also, there are websites such as 23andme, Ancestory.com, GeneticGenie.org that claim to provide gene tests including a test for MTHR gene test as well. Some DNA test kits are available on Amazon as well for this test 23andMe DNA Test - Health + Ancestry Personal Genetic Service - 75+ Online Reports - includes at-home saliva collection kitMETHYLFOLATE OVERDOSEIf Methylfolate is taken in excess then it can cause other issues such as anxiety, hyperactivity, insomnia, depression, etc. So it is best to stick to the doctor's prescribed dosage on this matter.

This is the only brand I purchase and I regularly recommend this brand to clients. High quality with consistent results, no negative side effects to note, and easy to use.I have been using this brand for years. I’ve tried other brands and none have worked as well as this one!This has been a game changer for improving mood and overall wellbeing!

This product works as a supplement. Good value and quality for price. Will buy again

This is a supplement that can be difficult to find in this particular strength. The capsule is a bit large, but it is much easier to swallow than tablets. I prefer taking just one of these capsules instead of five little tablets! If you have certain gene mutations, this supplement can totally change your life for the better!

MD Life L Methylfolate 1mg is easy to swallow. I have issues swallowing large pills so that is why I ordered only the 1 mg size.

I use daily as suggested by my doctor.

Worked great!

I would like to know exactly why this md life company advertises this l methylfolate product on Amazon as different ingredients that what I received. The ingredients list on Amazon says it contains vegetable capsule and CELLULOSE. On my bottles I have received, the ingredients list vegetable capsule and CORN FIBER! Which is it? People that are pregnant are using this product and there is false advertising of this product here on Amazon.